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rabbit polyclonal anti p irs 1 ser312  (Thermo Fisher)


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    Thermo Fisher rabbit polyclonal anti p irs 1 ser312
    The effect of 14-weeks of CON, WHEY or KDPWHE treatment in adults with type-2 diabetes mellitus on phosphoprotein concentration within the insulin-receptor signalling pathway upstream of regulatory nodes for GLUT4 translocation within the skeletal muscle in responses to basal (INS -) and insulin stimulation (hyperinsulinemic-isoglycaemic; INS +), with data shown as relative protein abundance at week 0 and 15. (A) Insulin-receptor substrate-1 phosphorylated on <t>Ser312</t> <t>(IRS-1</t> Ser312 ). (B) Representative immunofluorescence images of cross-sectional skeletal muscle fibres stained for IRS-1 Ser312 . IRS-1 ser312 was measured as staining intensity in the plasma membrane region (SM ). The small grey scale lines bottom right represent 50 μm. (C) Protein kinase B phosphorylation on Ser437 (Akt Ser437 ) expressed relative to total Akt. (D) Akt substrate 160 kDa phosphorylation on Thr642 (AS160 Thr642 ), (E) p21 activated kinase (PAK) phosphorylation on isoform 1 (PAK Thr423 ) and 2 (PAK Thr402 ). Data are raw unit median, upper and lower quartiles, and range, with individual-participant data points included. Raw unit point and change score mean and SD are in SM Data 1. Outcome statistics are in . CON, non-protein isocaloric control; KDPWHE, keratin-derived protein with whey; WHEY, whey protein isolate.
    Rabbit Polyclonal Anti P Irs 1 Ser312, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rabbit+polyclonal+anti+p+irs+1+ser312/pmc10570009-256-30-34
    Average 86 stars, based on 1 article reviews
    rabbit polyclonal anti p irs 1 ser312 - by Bioz Stars, 2026-09
    86/100 stars

    Images

    1) Product Images from "Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes"

    Article Title: Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes

    Journal: Redox Biology

    doi: 10.1016/j.redox.2023.102918

    The effect of 14-weeks of CON, WHEY or KDPWHE treatment in adults with type-2 diabetes mellitus on phosphoprotein concentration within the insulin-receptor signalling pathway upstream of regulatory nodes for GLUT4 translocation within the skeletal muscle in responses to basal (INS -) and insulin stimulation (hyperinsulinemic-isoglycaemic; INS +), with data shown as relative protein abundance at week 0 and 15. (A) Insulin-receptor substrate-1 phosphorylated on Ser312 (IRS-1 Ser312 ). (B) Representative immunofluorescence images of cross-sectional skeletal muscle fibres stained for IRS-1 Ser312 . IRS-1 ser312 was measured as staining intensity in the plasma membrane region (SM ). The small grey scale lines bottom right represent 50 μm. (C) Protein kinase B phosphorylation on Ser437 (Akt Ser437 ) expressed relative to total Akt. (D) Akt substrate 160 kDa phosphorylation on Thr642 (AS160 Thr642 ), (E) p21 activated kinase (PAK) phosphorylation on isoform 1 (PAK Thr423 ) and 2 (PAK Thr402 ). Data are raw unit median, upper and lower quartiles, and range, with individual-participant data points included. Raw unit point and change score mean and SD are in SM Data 1. Outcome statistics are in . CON, non-protein isocaloric control; KDPWHE, keratin-derived protein with whey; WHEY, whey protein isolate.
    Figure Legend Snippet: The effect of 14-weeks of CON, WHEY or KDPWHE treatment in adults with type-2 diabetes mellitus on phosphoprotein concentration within the insulin-receptor signalling pathway upstream of regulatory nodes for GLUT4 translocation within the skeletal muscle in responses to basal (INS -) and insulin stimulation (hyperinsulinemic-isoglycaemic; INS +), with data shown as relative protein abundance at week 0 and 15. (A) Insulin-receptor substrate-1 phosphorylated on Ser312 (IRS-1 Ser312 ). (B) Representative immunofluorescence images of cross-sectional skeletal muscle fibres stained for IRS-1 Ser312 . IRS-1 ser312 was measured as staining intensity in the plasma membrane region (SM ). The small grey scale lines bottom right represent 50 μm. (C) Protein kinase B phosphorylation on Ser437 (Akt Ser437 ) expressed relative to total Akt. (D) Akt substrate 160 kDa phosphorylation on Thr642 (AS160 Thr642 ), (E) p21 activated kinase (PAK) phosphorylation on isoform 1 (PAK Thr423 ) and 2 (PAK Thr402 ). Data are raw unit median, upper and lower quartiles, and range, with individual-participant data points included. Raw unit point and change score mean and SD are in SM Data 1. Outcome statistics are in . CON, non-protein isocaloric control; KDPWHE, keratin-derived protein with whey; WHEY, whey protein isolate.

    Techniques Used: Concentration Assay, Translocation Assay, Immunofluorescence, Staining, Membrane, Derivative Assay

    The effect of 14-weeks of KDPWHE, WHEY, or CON treatment in adults with type-2 diabetes mellitus on skeletal muscle tissue insulin signalling, capillarization, and capillary endothelial nitric oxide synthase activity.
    Figure Legend Snippet: The effect of 14-weeks of KDPWHE, WHEY, or CON treatment in adults with type-2 diabetes mellitus on skeletal muscle tissue insulin signalling, capillarization, and capillary endothelial nitric oxide synthase activity.

    Techniques Used: Activity Assay



    Similar Products

    rabbit polyclonal anti p irs 1 ser312  (Thermo Fisher)
    86
    Thermo Fisher rabbit polyclonal anti p irs 1 ser312
    The effect of 14-weeks of CON, WHEY or KDPWHE treatment in adults with type-2 diabetes mellitus on phosphoprotein concentration within the insulin-receptor signalling pathway upstream of regulatory nodes for GLUT4 translocation within the skeletal muscle in responses to basal (INS -) and insulin stimulation (hyperinsulinemic-isoglycaemic; INS +), with data shown as relative protein abundance at week 0 and 15. (A) Insulin-receptor substrate-1 phosphorylated on <t>Ser312</t> <t>(IRS-1</t> Ser312 ). (B) Representative immunofluorescence images of cross-sectional skeletal muscle fibres stained for IRS-1 Ser312 . IRS-1 ser312 was measured as staining intensity in the plasma membrane region (SM ). The small grey scale lines bottom right represent 50 μm. (C) Protein kinase B phosphorylation on Ser437 (Akt Ser437 ) expressed relative to total Akt. (D) Akt substrate 160 kDa phosphorylation on Thr642 (AS160 Thr642 ), (E) p21 activated kinase (PAK) phosphorylation on isoform 1 (PAK Thr423 ) and 2 (PAK Thr402 ). Data are raw unit median, upper and lower quartiles, and range, with individual-participant data points included. Raw unit point and change score mean and SD are in SM Data 1. Outcome statistics are in . CON, non-protein isocaloric control; KDPWHE, keratin-derived protein with whey; WHEY, whey protein isolate.
    Rabbit Polyclonal Anti P Irs 1 Ser312, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rabbit+polyclonal+anti+p+irs+1+ser312/pmc10570009-256-30-34
    Average 86 stars, based on 1 article reviews
    rabbit polyclonal anti p irs 1 ser312 - by Bioz Stars, 2026-09
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    The effect of 14-weeks of CON, WHEY or KDPWHE treatment in adults with type-2 diabetes mellitus on phosphoprotein concentration within the insulin-receptor signalling pathway upstream of regulatory nodes for GLUT4 translocation within the skeletal muscle in responses to basal (INS -) and insulin stimulation (hyperinsulinemic-isoglycaemic; INS +), with data shown as relative protein abundance at week 0 and 15. (A) Insulin-receptor substrate-1 phosphorylated on Ser312 (IRS-1 Ser312 ). (B) Representative immunofluorescence images of cross-sectional skeletal muscle fibres stained for IRS-1 Ser312 . IRS-1 ser312 was measured as staining intensity in the plasma membrane region (SM ). The small grey scale lines bottom right represent 50 μm. (C) Protein kinase B phosphorylation on Ser437 (Akt Ser437 ) expressed relative to total Akt. (D) Akt substrate 160 kDa phosphorylation on Thr642 (AS160 Thr642 ), (E) p21 activated kinase (PAK) phosphorylation on isoform 1 (PAK Thr423 ) and 2 (PAK Thr402 ). Data are raw unit median, upper and lower quartiles, and range, with individual-participant data points included. Raw unit point and change score mean and SD are in SM Data 1. Outcome statistics are in . CON, non-protein isocaloric control; KDPWHE, keratin-derived protein with whey; WHEY, whey protein isolate.

    Journal: Redox Biology

    Article Title: Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes

    doi: 10.1016/j.redox.2023.102918

    Figure Lengend Snippet: The effect of 14-weeks of CON, WHEY or KDPWHE treatment in adults with type-2 diabetes mellitus on phosphoprotein concentration within the insulin-receptor signalling pathway upstream of regulatory nodes for GLUT4 translocation within the skeletal muscle in responses to basal (INS -) and insulin stimulation (hyperinsulinemic-isoglycaemic; INS +), with data shown as relative protein abundance at week 0 and 15. (A) Insulin-receptor substrate-1 phosphorylated on Ser312 (IRS-1 Ser312 ). (B) Representative immunofluorescence images of cross-sectional skeletal muscle fibres stained for IRS-1 Ser312 . IRS-1 ser312 was measured as staining intensity in the plasma membrane region (SM ). The small grey scale lines bottom right represent 50 μm. (C) Protein kinase B phosphorylation on Ser437 (Akt Ser437 ) expressed relative to total Akt. (D) Akt substrate 160 kDa phosphorylation on Thr642 (AS160 Thr642 ), (E) p21 activated kinase (PAK) phosphorylation on isoform 1 (PAK Thr423 ) and 2 (PAK Thr402 ). Data are raw unit median, upper and lower quartiles, and range, with individual-participant data points included. Raw unit point and change score mean and SD are in SM Data 1. Outcome statistics are in . CON, non-protein isocaloric control; KDPWHE, keratin-derived protein with whey; WHEY, whey protein isolate.

    Article Snippet: The following antibodies were used for visualization of insulin signalling: 1:250 anti-GLUT4 rabbit polyclonal primary antibody (Abcam, catalogue # ab654) [ ], 1:500 mouse polyclonal anti-dystrophin (Sigma-Aldrich, catalogue #D8168), 1:500 rabbit polyclonal anti-p-IRS-1 Ser312 (Invitrogen, catalogue # PA1-1054, p-IRS-1Ser307 in rodent), 1:100 rabbit polyclonal anti-eNOS (Abcam, catalogue # Ab5589), 1:100 rabbit polyclonal anti-p-eNOS Ser1177 (Abcam, catalogue # ab184154) or 1:100 rabbit polyclonal anti-NOX2 (Abcam, catalogue # ab80508) as primary antibodies.

    Techniques: Concentration Assay, Translocation Assay, Immunofluorescence, Staining, Membrane, Derivative Assay

    The effect of 14-weeks of KDPWHE, WHEY, or CON treatment in adults with type-2 diabetes mellitus on skeletal muscle tissue insulin signalling, capillarization, and capillary endothelial nitric oxide synthase activity.

    Journal: Redox Biology

    Article Title: Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes

    doi: 10.1016/j.redox.2023.102918

    Figure Lengend Snippet: The effect of 14-weeks of KDPWHE, WHEY, or CON treatment in adults with type-2 diabetes mellitus on skeletal muscle tissue insulin signalling, capillarization, and capillary endothelial nitric oxide synthase activity.

    Article Snippet: The following antibodies were used for visualization of insulin signalling: 1:250 anti-GLUT4 rabbit polyclonal primary antibody (Abcam, catalogue # ab654) [ ], 1:500 mouse polyclonal anti-dystrophin (Sigma-Aldrich, catalogue #D8168), 1:500 rabbit polyclonal anti-p-IRS-1 Ser312 (Invitrogen, catalogue # PA1-1054, p-IRS-1Ser307 in rodent), 1:100 rabbit polyclonal anti-eNOS (Abcam, catalogue # Ab5589), 1:100 rabbit polyclonal anti-p-eNOS Ser1177 (Abcam, catalogue # ab184154) or 1:100 rabbit polyclonal anti-NOX2 (Abcam, catalogue # ab80508) as primary antibodies.

    Techniques: Activity Assay